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KMID : 0043319980210060749
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Archives of Pharmacal Research
1998 Volume.21 No. 6 p.749 ~ p.752
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Synthesis and In Vitro Cytotoxicity of 3- or 4-Dialkylaminomethyl-1-azaanthraquinones
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Lee Hee-Soon
Choi Jae-Young
Lee Seung-Il
Hong Seong-Soo
Cho Jung-Sook
Kim Young-Ho
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Abstract
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Six 3-dialkylaminomethyl-1-azaanthraquinones and five 4-dialkylaminomethyl-1-azaanthraquinones were synthesized and evaluated in vitro cytotoxicity against four human can cer cell lines. The compounds retained much of their cytotoxic activity against the multi-drug-resistant cell line (KB-V-1) as shown by resistance index.
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KEYWORD
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Antitumor agents, Azaanthraquinone, Cytotoxic activity, Doxorubicin, Mitoxantrone
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